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(a) Picture ( left ) and schematic ( right ) of the Implant location of M1 and S1 intracortical arrays. ( b ) Top : Example heatmap of average peak to peak amplitudes of cortical evoked potentials from VLL stimulation at 10 Hz across all channels over S1 and M1 for MK-HS. Center : Example stimulation triggered averages of cortical evoked potentials over S1 and M1 (n=40 traces). Bottom : Histogram of peak to peak amplitudes across all channels for S1 and M1 (n=48 channels per array). ( c ) Top : Example baseline corrected spike count heatmaps in S1 and M1 for MK-HS. Bottom : Average spike counts over time across all channels in S1 and M1 array (n=48 channels per array). (d) Top : Example traces of antidromic potentials in M1 from IC stimulation without (yellow) and with (blue) conditioning from a burst of VLL stimulation for MK-HS (n=40 traces). Boxplot of peak to peak amplitude of the antidromic potentials when IC stimulation is conditioned by VLL stimulation at various delays (2, 5, 10, and 50ms). In the boxplot, the whiskers extend to the maximum spread not considering outliers, central, top, and bottom lines represent median, 25 th , and 75 th percentile, respectively. For all panels, statistical significance was assessed with two-tail bootstrapping with Bonferroni correction: p<0.05 (*), p<0.01 (**), p<0.001(***).
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(a) Picture ( left ) and schematic ( right ) of the Implant location of M1 and S1 intracortical arrays. ( b ) Top : Example heatmap of average peak to peak amplitudes of cortical evoked potentials from VLL stimulation at 10 Hz across all channels over S1 and M1 for MK-HS. Center : Example stimulation triggered averages of cortical evoked potentials over S1 and M1 (n=40 traces). Bottom : Histogram of peak to peak amplitudes across all channels for S1 and M1 (n=48 channels per array). ( c ) Top : Example baseline corrected spike count heatmaps in S1 and M1 for MK-HS. Bottom : Average spike counts over time across all channels in S1 and M1 array (n=48 channels per array). (d) Top : Example traces of antidromic potentials in M1 from IC stimulation without (yellow) and with (blue) conditioning from a burst of VLL stimulation for MK-HS (n=40 traces). Boxplot of peak to peak amplitude of the antidromic potentials when IC stimulation is conditioned by VLL stimulation at various delays (2, 5, 10, and 50ms). In the boxplot, the whiskers extend to the maximum spread not considering outliers, central, top, and bottom lines represent median, 25 th , and 75 th percentile, respectively. For all panels, statistical significance was assessed with two-tail bootstrapping with Bonferroni correction: p<0.05 (*), p<0.01 (**), p<0.001(***).
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(a) Picture ( left ) and schematic ( right ) of the Implant location of M1 and S1 intracortical arrays. ( b ) Top : Example heatmap of average peak to peak amplitudes of cortical evoked potentials from VLL stimulation at 10 Hz across all channels over S1 and M1 for MK-HS. Center : Example stimulation triggered averages of cortical evoked potentials over S1 and M1 (n=40 traces). Bottom : Histogram of peak to peak amplitudes across all channels for S1 and M1 (n=48 channels per array). ( c ) Top : Example baseline corrected spike count heatmaps in S1 and M1 for MK-HS. Bottom : Average spike counts over time across all channels in S1 and M1 array (n=48 channels per array). (d) Top : Example traces of antidromic potentials in M1 from IC stimulation without (yellow) and with (blue) conditioning from a burst of VLL stimulation for MK-HS (n=40 traces). Boxplot of peak to peak amplitude of the antidromic potentials when IC stimulation is conditioned by VLL stimulation at various delays (2, 5, 10, and 50ms). In the boxplot, the whiskers extend to the maximum spread not considering outliers, central, top, and bottom lines represent median, 25 th , and 75 th percentile, respectively. For all panels, statistical significance was assessed with two-tail bootstrapping with Bonferroni correction: p<0.05 (*), p<0.01 (**), p<0.001(***).
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Image Search Results


(a) Picture ( left ) and schematic ( right ) of the Implant location of M1 and S1 intracortical arrays. ( b ) Top : Example heatmap of average peak to peak amplitudes of cortical evoked potentials from VLL stimulation at 10 Hz across all channels over S1 and M1 for MK-HS. Center : Example stimulation triggered averages of cortical evoked potentials over S1 and M1 (n=40 traces). Bottom : Histogram of peak to peak amplitudes across all channels for S1 and M1 (n=48 channels per array). ( c ) Top : Example baseline corrected spike count heatmaps in S1 and M1 for MK-HS. Bottom : Average spike counts over time across all channels in S1 and M1 array (n=48 channels per array). (d) Top : Example traces of antidromic potentials in M1 from IC stimulation without (yellow) and with (blue) conditioning from a burst of VLL stimulation for MK-HS (n=40 traces). Boxplot of peak to peak amplitude of the antidromic potentials when IC stimulation is conditioned by VLL stimulation at various delays (2, 5, 10, and 50ms). In the boxplot, the whiskers extend to the maximum spread not considering outliers, central, top, and bottom lines represent median, 25 th , and 75 th percentile, respectively. For all panels, statistical significance was assessed with two-tail bootstrapping with Bonferroni correction: p<0.05 (*), p<0.01 (**), p<0.001(***).

Journal: medRxiv

Article Title: POTENTIATION OF CORTICO-SPINAL OUTPUT VIA TARGETED ELECTRICAL STIMULATION OF THE MOTOR THALAMUS

doi: 10.1101/2023.03.08.23286720

Figure Lengend Snippet: (a) Picture ( left ) and schematic ( right ) of the Implant location of M1 and S1 intracortical arrays. ( b ) Top : Example heatmap of average peak to peak amplitudes of cortical evoked potentials from VLL stimulation at 10 Hz across all channels over S1 and M1 for MK-HS. Center : Example stimulation triggered averages of cortical evoked potentials over S1 and M1 (n=40 traces). Bottom : Histogram of peak to peak amplitudes across all channels for S1 and M1 (n=48 channels per array). ( c ) Top : Example baseline corrected spike count heatmaps in S1 and M1 for MK-HS. Bottom : Average spike counts over time across all channels in S1 and M1 array (n=48 channels per array). (d) Top : Example traces of antidromic potentials in M1 from IC stimulation without (yellow) and with (blue) conditioning from a burst of VLL stimulation for MK-HS (n=40 traces). Boxplot of peak to peak amplitude of the antidromic potentials when IC stimulation is conditioned by VLL stimulation at various delays (2, 5, 10, and 50ms). In the boxplot, the whiskers extend to the maximum spread not considering outliers, central, top, and bottom lines represent median, 25 th , and 75 th percentile, respectively. For all panels, statistical significance was assessed with two-tail bootstrapping with Bonferroni correction: p<0.05 (*), p<0.01 (**), p<0.001(***).

Article Snippet: We then implanted intracortical arrays in M1 (48 channels) and S1 (48 channels) for a total of 96 channels (400μm pitch, electrode length 1.0mm Blackrock Microsystems, Salt Lake City, UT, USA).

Techniques: